Anti-inflammatory and anti-fibrotic effects of ursodeoxycholic acid in streptozocin-induced diabetic rats
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چکیده
منابع مشابه
Anti-Diabetic Effects of Amygdalus Lycioides Spach in Streptozocin-Induced Diabetic Rats
Diabetes mellitus is a group of metabolic disorders characterized by elevated blood sugarand abnormalities in insulin secretion and action. There are many anti-diabetic plants, whichmight supply useful sources for developing new medicines that can be used in treatment ofdiabetes mellitus. The primary objective of the present investigation is to evaluate the antidiabeticproperties of the aerial ...
متن کاملAnti-Diabetic Effects of Amygdalus Lycioides Spach in Streptozocin-Induced Diabetic Rats
Diabetes mellitus is a group of metabolic disorders characterized by elevated blood sugarand abnormalities in insulin secretion and action. There are many anti-diabetic plants, whichmight supply useful sources for developing new medicines that can be used in treatment ofdiabetes mellitus. The primary objective of the present investigation is to evaluate the antidiabeticproperties of the aerial ...
متن کاملGamma Linolenic Acid Exerts Anti-Inflammatory and Anti-Fibrotic Effects in Diabetic Nephropathy
PURPOSE This study was undertaken to investigate the effects of gamma linolenic acid (GLA) on inflammation and extracellular matrix (ECM) synthesis in mesangial and tubular epithelial cells under diabetic conditions. MATERIALS AND METHODS Sprague-Dawley rats were intraperitoneally injected with either a diluent [n=16, control (C)] or streptozotocin [n=16, diabetes (DM)], and eight rats each f...
متن کاملAnti-inflammatory and anti-fibrotic effects of sirolimus on bleomycin-induced pulmonary fibrosis in rats.
PURPOSE Pulmonary fibrosis is a devastating disease with a poor prognosis. Although the diagnosis and pathophysiology of this disease have been better characterized over the past few years, there is no effective therapy for the disease. The aim of this study was to evaluate the anti-inflammatory and anti-fibrotic effects of sirolimus (SRL), which is a potential anti-fibrotic agent, by using ble...
متن کاملRuscogenin ameliorates diabetic nephropathy by its anti-inflammatory and anti-fibrotic effects in streptozotocin-induced diabetic rat
BACKGROUND Ruscogenin is a major steroid sapogenin in the traditional Chinese herb Ophiopogon japonicus that have multiple bioactivities. Recent studies have demonstrated that ruscogenin is involved in down-regulation of intercellular adhesion molecule-1 (ICAM-1) and nuclear factor-κB (NF-κB) activation in anti-inflammatory pathways. We hypothesized that ruscogenin protects against diabetic nep...
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ژورنال
عنوان ژورنال: Kocaeli Medical Journal
سال: 2020
ISSN: 2147-0758
DOI: 10.5505/ktd.2020.64507